Product Description

Product Name: 1-(Adamantane-1-carbonyl) proline

English Name: 1-(1-Adamantylcarbonyl) proline

Alternative Names: 1-(1-ADAMANTYLCARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID; 1-(ADAMANTANE-1-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID; 1-(1-Adamantylcarbonyl)proline; L-Proline, 1-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-

CAS No.: 35084-48-1

Molecular Formula: C16H23NO3

Molecular Weight: 277.36

Purity: 98%

Appearance: White powder

Packaging: 1 kg/bag; 25 kg/drum

Storage Conditions: Store in a sealed, dry, room temperature environment away from direct sunlight.

Note: All products of this company are for export only, intended for laboratory and research use in legal and non-patented regions. Personal or animal use is strictly prohibited, and those who misuse it illegally are fully responsible for any consequences.


1. Product Introduction: ACA is a phenylalanine derivative, also known as adamantane carbonyl proline or Ad-Pro. It is mainly used as a catalyst or chiral separation reagent in organic synthesis. Studies have shown that ACA can catalyze asymmetric nucleophilic addition reactions, such as the reaction between aldehydes and alkyl azides, aldehydes and sulfonamidines, aldehydes and nitromethane, etc. In these reactions, the catalyst exhibits the highest activity towards alkyl azides addition. ACA can also catalyze asymmetric amination reactions. ACA serves as a chiral catalyst for asymmetric alcoholization. For example, it can react alcohols with aldehydes or ketones to produce corresponding aldol or hydroxyketone products. As a chiral organic compound, ACA has excellent catalytic activity.


2. Features:

(1) ACA is a white or off-white powder with good solubility. It has low solubility in water but typically good solubility in organic solvents. It is a stable compound that can be stored long-term at room temperature.

(2) ACA is a chiral molecule with two enantiomers. Its chirality makes it widely used in chiral synthesis. Usually, due to its good chiral induction, only one chiral isomer should be used.

(3) High Purity: ACA can be produced through refined manufacturing processes to achieve high purity. High purity means better bioavailability and fewer adverse reactions.

(4) Stability: ACA has good stability and maintains its activity and effectiveness under different environmental and storage conditions.


3. Applications: ACA is a nitrogen-containing organic compound, appearing as a white or off-white powder, and is used as an intermediate and other applications in pharmaceuticals. Additionally, due to its unique chiral properties, it is widely applied in chiral organic synthesis, including asymmetric nucleophilic addition reactions, amination reactions, alcoholization reactions, etc.

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